Part of Main Street in Rochester, East Main Street runs eastward from Four Corners in the center of the city. Four Corners is at the intersection of East Main Street, West Main Street, State Street to the north and Exchange Street to the south, and was the site of some of the city's earliest buildings. East Main also intersects with Prince Street.
From the Four Corners, East Main Street crosses the Genesee River and moves past the Liberty Pole at the intersection with East Avenue. This section of the street is highly developed, and fronted with many multi-storied buildings, including the Convention Center, the Hyatt Regency Hotel, the now-defunct Midtown Plaza complex, the Damon City Center branch of Monroe Community College, the Lincoln Tower, et alia. Aqueduct Park makes for a nice resting place with scenic views of the river.
Eastward from the Liberty Pole, East Main Street is faced by lower buildings of one to six stories, until it crosses over the Inner Loop expressway, which is the common boundary of Rochester's "downtown". Moving east from there, a small commercial district of restaurants and auto services leads past the Auditorium Theater and the former Armory, to a high bridge over the main railroad right-of-way into downtown.
Over the railroad bridge, East Main Street takes a slight veer to the right at the intersection with North Goodman Street, and continues east to Culver Road, past a mixture of light industrial, service, and residential buildings.
Just east of Culver Road, the defining feature is East High School, which supports a few fast-food restaurants in the area. Further to the east, Main Street runs past residences, storefronts, and former residential properties converted to office space. A sprinkling of dozen-unit apartment buildings dot this section of East Main Street, as well as restaurants and bars.
East Main Street ends at North Winton Road, amid a cluster of commercial and residential buildings, including a minor shopping plaza, services, and a few nicer eateries.