| Rochester closings in 2025 | ||
| Unknown | Smokers Choice - Henrietta and Chili locations | |
| Unknown | Kirkland's | |
| Unknown | Wall Street Bar and Grill | |
| Unknown | The Rabbit Room | |
| Unknown | Pi Craft Pizza | |
| January | Smashburger | |
| January | Stylicious | |
| January 17 | Farmers Creekside Inn | |
| January 25 | Roc Style Chicken & Burger | |
| February | Moe's Southwest Grill - College Town | |
| February | Broth | |
| February 1 | Petit Poutinerie | |
| February 28 | Copper Leaf Brewing | |
| February 28 | Essex | |
| March | Park Avenue Pub | |
| March | Raw Leaf | |
| March | Mitchell's Pub and Grub | |
| March 2 | The Cub Room | |
| March 2 | Spot Coffee | |
| March 15 | Big Lots - Henrietta location | |
| March 16 | Gaetano’s Bakery | |
| March 31 | Party City - All locations | |
| March 31 | Big Lots - All locations | |
| April | Qik Noodles | |
| April | Caramel Bakery and Bar | |
| April 25 | DGX | |
| May 8 | Bagels Etc. | |
| May 14 | Papito's Burritos | |
| May 14 | Jo-Ann Fabric & Crafts - All locations | |
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