| Rochester Openings in 2022 | ||
| Unknown | Martusciello Bakery | |
| Unknown | Craft Cafe | |
| Unknown | Ashley Furniture - Greece location | |
| Unknown | Salon Hermitage | |
| Unknown | Hue Salons | |
| January | CVS - Tops Brighton Plaza | |
| January | Brick & Ivy | |
| January 31 | Bay Side Pub | |
| February 12 | Scott's Hallmark Shop - Irondequoit location | |
| February 17 | Scott's Hallmark Shop - Penfield location | |
| March 31 | Bay Goodman Pizza | |
| April 30 | Dolce Italy Rochester | |
| April 30 | Caribbean Heritage Restaurant | |
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