William Pitkin was Rochester's 12th mayor. He served as mayor from 1845 to 1846. He replaced John Allen as mayor, and in 1846 he was succeeded by Samuel George Andrews.
Pitkin was born in 1790. He married Louisa Lucinda Rochester, daughter of Nathaniel Rochester, on June 20, 1848 at St. Luke's Church in Rochester. He died on April 4, 1869, and is buried in Mt. Hope Cemetery. His wife Louisa died on July 2, 1903, and is also buried in Mt. Hope Cemetery.1
Pitkin was one of the owners of the Chase Brothers Nursery, which later became the regional home improvement store Chase-Pitkin.