Rochester has mediocre public transit, but you can do OK getting around if you are visiting. The public transit system is a 'spoke' (and no hub!) system, to encourage people to come downtown. Instead it often has the effect of encouraging people to skip the public transit, and bike or rideshare instead.
Intracity
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Rochester-Genesee Regional Transportation Authority — aka, "the bus"
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Also includes RTS Access - a service for people with disabilities.
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See also RGRTA Transit Center
Intercity
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Amtrak Station - for passenger train service
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Greyhound - currently located near the Amtrak Station
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Greater Rochester International Airport - our local airport
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MegaBus - stops on Pitkin St. downtown near Broad Street
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New York Trailways - currently located near the Amtrak Station
Nebulous Plans
See Also
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RTS Transit Center - Central bus hub.