| Rochester Openings in 2022 | ||
| Unknown | Martusciello Bakery | |
| Unknown | Craft Cafe | |
| Unknown | Ashley Furniture - Greece location | |
| Unknown | Salon Hermitage | |
| Unknown | Hue Salons | |
| Unknown | Jeffrey's Bar | |
| Unknown | Starbucks - Henrietta Plaza and Monroe Village | |
| Unknown | Cost Cutters | |
| Unknown | Riot Room | |
| Unknown | Primo's Diner | |
| Unknown | Diplomat Banquet Center | |
| January | CVS - Tops Brighton Plaza | |
| January | Brick & Ivy | |
| January 31 | Bay Side Pub | |
| February 12 | Scott's Hallmark Shop - Irondequoit location | |
| February 17 | Scott's Hallmark Shop - Penfield location | |
| March 31 | Bay Goodman Pizza | |
| April 30 | Dolce Italy Rochester | |
| April 30 | Caribbean Heritage Restaurant | |
| May 1 | Sweet Mist | |
| June | Rowe Photo | |
| June | Pittsford Cinema | |
| June | Lucca Kitchen & Cocktails | |
| June 26 | Northside Inn | |
| July 2 | McCann's Local Meats | |
| July 31 | Brownstein's Deli & Bakery | |